Chris Froome was taken to the hospital Wednesday after falling on a training run for the Criterium du Dauphine 4th stage individual time-trial, Team Ineos said.
The team confirmed that Froome would take no further part in the race.
"Team INEOS can confirm that Chris Froome crashed during a recon of stage four of the Criterium du Dauphine today. He is currently on his way to a local hospital and won't start today's fourth stage. We will provide a further update in due course," Ineos said on Twitter.
The 34-year-old Froome is a three time winner at this race considered a form guide to the Tour de France, which starts in Brussels July 6.
At the Criterium Froome was seeking to fine tune his form having failed to win a stage yet this season, but was eighth overall just 24 seconds off the pace in the Crtiterium.
During Froome's training run on Wednesday conditions were windy but the roads were dry with the route presenting no difficulties apart from two well-signalled downhill bends.
Ineos also have defending champion Geraint Thomas in their ranks with the Welshman scheduled to take part at the eight-stage Tour de Suisse which starts Sunday.